连续血糖监测是糖尿病预防、诊断及管理过程中的有效手段。然而，现有的电化学连续血糖监测系统仍存在开放式创口植入、易引起炎症、监测时间短等缺点。光学传感为连续血糖监测提供了新方法，本团队设计开发了可见光激发的发光纳米粒子葡萄糖传感器，其高亮度的发光传感特性有助于经皮血糖信号检测。基于比率荧光策略设计的发光纳米粒子可以校准激发光强变化和采样环境变化等带来的信号误差，可见光激发发光特性可以避免紫外光激发采样对机体的伤害，在高频率长时段的信号采集应用中具有明显优势。

This study investigated the neural mechanisms located in the prefrontal cortex (PFC) involved in maintaining addictive-like eating behavior. Therefore, we aimed to fill a gap in the existing literature and help clarify the food addiction (FA) cycle by inspecting the relationship between the executive control and psychopathology involved in the FA cycle. Twenty-three students recruited from the University of Macau participated in this study. We investigated a hemodynamic response captured by NIRS recordings, activated during n-back, set-shifting, and go/nogo paradigms. Moreover, we investigated the FA symptoms through the YFAS clinical inventory to better understand the relationship between hemodynamic response and clinical symptomatology in college students. First, the hemodynamic findings confirm that altered cognitive control in executive function performance appears to be linked to addictive-like eating behaviors, which in turn confirms a circuit similarity between FA and the substance abuse population (SUD) as reported in previous fMRI studies. Secondly, the psychological findings confirm the significant association between the working memory deficits and symptoms severity which suggest the role of self-control and regulation in limiting the storage resources as a potential trigger to develop overconsumption episodes in the FA cycle. Our findings highlight how disrupted self-control and regulation of craving and negative affect induced by mental imagery might shape and overload the working memory storage as a potential trigger to develop binge eating episodes to maintain the FA cycle. In conclusion, the use of fNIRS in the context of eating disorders studies represents a valuable application, noninvasive, and patientfriendly tool, providing new insights into understanding the addiction cycle and treatment guidelines.

利用特殊的散热设计，在Tm∶ZBLAN玻璃激光器中实现连续和被动调Q锁模运转。分别采用透过率为1.5%、3%、5%的输出镜在激光连续运转时获得254 mW、296 mW、230 mW的最高输出功率。为了实现锁模运转，选用透过率为1.5%的输出镜，将透射式GaAs-SESAM作为锁模元件，出光阈值仅为131 mW，当吸收泵浦功率大于1.09 W时，实现了稳定的调Q锁模运转，最大输出功率为98 mW，调Q包络脉冲宽度为6 μs，重复频率为19.23 kHz，调Q包络下脉冲的重复频率为102 MHz，脉冲宽度约为800 ps，最大单脉冲能量为0.96 nJ。

利用固态反应烧结方法制做的混合三氧化物陶瓷Tm∶LuScO3作为激光增益介质，在全固态激光器中实现了稳定的调Q锁模运转。利用透过率为3%的输出镜获得最高连续光输出功率为257 mW，中心波长为1 993 nm，对应斜效率14.06%。以三种半导体可饱和吸收镜(SESAM)作为锁模启动元件,系统分析了Tm∶LuScO3陶瓷激光器的调Q锁模运转特性，获得最窄锁模脉冲宽度在749~891 ps之间，重复频率121.9 MHz，对应的调Q包络脉冲宽度为50 μs，重复频率45.45 kHz，最高输出功率167 mW，中心波长为1 987 nm，对应最大单脉冲能量为1.37 nJ。

以两个65 W的793 nm 激光二极管(LD)作为泵浦源,采用U型谐振腔结构进行高功率声光调Q运转实验研究。采用三种b轴切割的板条状镀金Tm∶YAP晶体作为增益介质,分析比较三种增益介质和不同腔参数组合对激光输出性能的影响。当最大泵浦功率为130 W时,连续激光输出的最大功率为42.5 W,斜率效率为42.5%。经过声光(AO)调制后,当重复频率为10 kHz时,调Q激光的最大平均输出功率为33.2 W,脉冲宽度为200 ns。将重复频率提高至40 kHz时,获得最短脉冲宽度为64 ns,相应平均功率为30 W,中心波长为1944 nm的激光输出。采用MATLAB软件仿真输出脉冲激光光斑的三维能量分布,光斑能量呈典型的高斯分布,可见光束质量较好。高功率Tm∶YAP激光器可作为3~5 μm中红外光学参量振荡器的泵浦源,在众多领域具有良好的应用前景和巨大的发展潜力。

首次采用氧化石墨烯可饱和吸收体作为锁模启动元件在Tm,Ho∶CaYAlO4激光器中实现了稳定的被动调Q锁模运转。在3%输出耦合镜下, Tm,Ho∶CaYAlO4固体激光器获得了最低为293 mW的连续光出光阈值。在腔内引入氧化石墨烯可饱和吸收体后, 当吸收抽运功率增大到1 859 mW时, Tm,Ho∶CaYAlO4激光器进入稳定的调Q锁模运转状态。当抽运功率达到3 W时, 获得中心波长为2 089 nm、斜效率为10.1%、对应最大输出功率为213 mW的被动调Q锁模脉冲, 重复频率为100 MHz, 调Q包络中锁模脉冲的调制深度接近100%。